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What is CONTRAVE?

Weight loss is not a one-size-fits-all approach. Learn how CONTRAVE can help you on your weight-loss journey.

  • CONTRAVE is an FDA-approved weight-loss medication for people who areoverweight with at least one serious medical condition, including diabetes,high blood pressure, etc., or those struggling with obesity.
  • It is uniquely designed to reduce hunger and control cravings,
    so you can lose weight and keep it off when combined with diet and exercise.
  • It is not a controlled substance, scheduled drug, or stimulant.
  • CONTRAVE is the #1 branded oral weight loss medication.**

**Based on the number of prescription fills for a brand name weight-loss drug in the IQVIA database July 2021 – June 2022

 
 
 
 
 
 
 

How CONTRAVE works

CONTRAVE targets 2 areas of thebrain that cause hunger and cravings

Hunger

happens when your brain tells you that it needs nutrition and that any food will satisfy this need.

Cravings

happen when your brain wants specific foods, even though you may not feel hungry.

Other areas of the brain may be involved. The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.

 
 
 
 
 
 
 
 

The Science Behind CONTRAVE

There’s A Scientific Reason You Are Struggling To Lose Weight & Keep it Off

Through science, we can better understand this challenge because it turns out your brain may be working against you by sending hunger signals or triggering cravings, even when you’re not hungry.

 
 
 
 
 
 
 

Our brains play a role in the struggle to lose weight:

The hunger center (hypothalamus) can increase hunger, telling you to eat again or eat more

The mesolimbic circuit or reward system can create cravings that seem uncontrollable even when you’re not hungry

CONTRAVE combines 2 medications that together reduce hunger and control cravings to help you lose weight and keep it off: bupropion HCI and naltrexone HCI.
Both medicines have well-established safety profiles and have been prescribed by doctors for other conditions for more than 30 years. However, the individual medicines in CONTRAVE are not approved for weight loss when used on their own, and CONTRAVE is not approved to treat depression or other mental illnesses, alcohol or opioid dependency, or to help people quit smoking.
 
 
 
 
 
 
 
HCI.
Both medicines have well-established safety profiles and have been prescribed by doctors for other conditions for more than 30 years. However, the individual medicines in CONTRAVE are not approved for weight loss when used on their own, and CONTRAVE is not approved to treat depression or other mental illnesses, alcohol or opioid dependency, or to help people quit smoking.

CONTRAVE was studied for efficacy and safety in several clinical trials

The efficacy and safety of CONTRAVE were assessed in the 56-week CONTRAVE Obesity Research (COR) clinical studies.

3

56-week
studies

2,322

patients

Proven Long-Term
Weight Loss

 
 
 
 
 
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